Measure noise figure of something with really low noise... Both PNA and Y-factor measurement options are sensitive to oscillations, and external sources making its way into the signal chain. Y-factor measurement depends on VSWR, and for sub-dB measurements, the ENR of the source is affecting the measurements, and can vary with calibration year per year. AFAIK accuracy with the newest USB-C sources from Keysight is in the range of +/- 0.2 dB NF with a known DUT (I have had the luxury of using a PNA and Y-factor equipped NFA side-by-side). PNA measurements are can be difficult as compression will affect the measurement.